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Boolean Networks as Predictive Models of Emergent Biological Behaviors: (Elements in the Structure and Dynamics of Complex Networks)

(Hardback)

Colin Campbell, Fatemeh Sadat Fatemi Nasrollahi, Réka Albert, Eli Newby,

Cambridge University Press (Publisher)

Published

2024

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Medicine and Nursing Medicine: general issues Medical and health informatics

By: Colin Campbell, Fatemeh Sadat Fatemi Nasrollahi, Réka Albert, Eli Newby | Publisher: Cambridge University Press | Released: 28 Mar 2024

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Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions – from molecules in gene regulatory networks to species in ecological networks – and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization.